General Electric Company

Tokitae LLC

Global Life Sciences Solutions Operations UK Ltd

Cytiva Sweden Ab

Cytiva Bioprocess R&d Ab

Cathryn Ellen Olsen

David Roger Moore

Matthew Jeremiah Misner

John Richard Nelson

Paul Michael Smigelski, Jr

Gregory Andrew Grossmann

Jimmy Lynn Webb

Brian Christopher Bales

Patrick Joseph McCloskey

Gary William Yeager

Bernhard Hans Weigl

Julia L Lee

Hongyi Zhou

Louisa Ruth Carr

John Thomas Connelly

Benjamin David Grant

Eric James Pressman

Robert Scott Duthie

Frank John Mondello

Vincent Francis Pizzi

Bing Li

Scott Michael Miller

William Christopher Alberts

Patrick Roland Lucien Malenfant

Jason Michael Nichols

Per Ola Lind

Stina Elisabeth Hallgren

Annika Morrison

Patrick Joseph Mccloskey

Louise Ruth Carr

Julia Lam Lee

Patrick Roland Malenfant

A device comprising a modified porous membrane is provided. The modified porous membrane comprises a polymer coating grafted to a porous membrane. The device is used for analyte detection from a biological sample using an immunoassay. The device comprises a sample application zone at one end of the device for applying a biological sample comprising a target analyte; and a detection zone present at another end of the device, downstream of the sample application zone for detecting the target analyte, wherein the detection zone comprises one or more first biomolecules immobilized on a modified porous membrane having a structure of Formula (I).

Porous membranes with a polymer grafting, methods and uses thereof

A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.

Device for rapid detection of tuberculosis-lipoarabinomannan (TB-LAM) with enhanced sensitivity

A rapid detection method of a target biomolecule comprising an antigenic moiety is provided. The method includes providing a source biological sample comprising the target biomolecule; contacting the source biological sample to an ion-exchange medium; eluting the captured-target biomolecule from the ion-exchange medium as an eluate, and loading the eluate to a rapid diagnostic testing device comprising an antibody. The eluate comprises a concentrated form of the biomolecule in a solution having a salt concentration greater than 150 mM. A concentration of the target biomolecule in the eluate is in a range from about 2&#xd7; to 25&#xd7; compared to a concentration of the biomolecule in the source biological sample. The target biomolecule binds to the antibody under the salt concentration of greater than 150 mM. A device for rapid detection of target biomolecule is also provided.

Method and associated device for rapid detection of target biomolecules with enhanced sensitivity

A membrane including a block copolymer is presented. The block copolymer includes at least one block A including structural units having a formula (I), and at least one block B including structural units having a formula (II). A hollow-fiber membrane for hemodialysis or hemofiltration, and associated block copolymer are also presented.

Zwitterion-functionalized block copolymer membranes and associated block copolymer composition

In one aspect, the present invention provides a curable composition useful in the preparation of a gas separation membrane. The curable composition comprises a polyvinyl alcohol; an aliphatic polyamine; a polyglycidyl ether; and a salt of a Cto Cheterocyclic amino acid. In another aspect the present invention provides a composition comprising a crosslinked polyvinyl alcohol comprising structural units derived from a polyglycidyl ether, a polyamine and the salt of a Cto Cheterocyclic amino acid. The compositions are useful in the preparation of gas separation membranes in which the Cto Cheterocyclic amino acid in the form of its salt functions as a mobile carrier of carbon dioxide.

Membranes comprising amino acid mobile carriers

The invention relates to a device for separating unwanted compounds from an antibody containing biological sample. The device comprises a porous support and a polymeric resin disposed within the pores of the porous support. The device may further comprise a viral clearance membrane upstream or downstream from the polymeric resin. Methods of use are also provided.

Membranes and associated methods for purification of antibodies

Silyl carbamates are prepared by reacting carbon dioxide with a silazane composition such as 2-methyl-2-sila-3-aza-5-hexene. The silyl carbamates may be converted to symmetrical bis(aminoalkyl)disiloxanes by hydrosilation followed by hydrolysis.

Silyl carbamates and their use in the preparation of bis (aminoalkyl)

Bis(aminoalkyl)disiloxanes such as 1,9-diamino-4,4,6,6-tetramethyl-5-oxa-4,6-disilanonane are prepared by contacting an acyclic olefinic silazane such as 2-methyl-2-sila-3-aza-5-hexene with a hydrosilation catalyst to form an intermediate which is then hydrolyzed. When certain olefinic silazanes are hydrosilated with a reaction product of a platinum compound with an olefinic siloxane, the intermediate is a composition comprising novel cyclic silazanes such as 1,1-dimethyl-1-sila-2-azacyclopentane.

Bis(aminoalkyl)disiloxanes and method and intermediates for their

Olefinic silazanes are prepared by the reaction of an olefinic amine such as allylamine with a silazane such as dimethylaminodimethylsilane or tetramethyldisilazane, preferably in the presence of a catalytic amount of a hydrogen halide source such as dimethylchlorosilane as catalyst. The highly volatile amino compound generated as a by-product (e.g., ammonia or dimethylamine) is lost by volatilization and this furnishes at least part of the driving force for the reaction.

Method for preparing olefinic silazanes

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Wilton, NY, United States of America

Cathryn Ellen Olsen