Warner-Lambert Company

Cathlin Marie Biwersi

Haile Tecle

Joseph Scott Warmus

Stephen Douglas Barrett

Michael David Kaufman

Michael Huai Gu Chen

The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystalline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.

Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids

Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, Calkoxy, or NROR; X is OR, NRR, or NR; inhibitors of MEK and are useful in the treatment of a variety of proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.

Substituted diarylamines as MEK inhibitors

The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystaline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.

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Lawrenceville, NJ, United States of America

Cathlin Marie Biwersi