The University of Texas System

Mission Pharmacal Company

Catherine Schein

Werner Braun

Mary Ann Walter

Scott R Gilbertson

Tor Savidge

Johnny W Peterson

Jian Gao

Petril Urvil

Petr Danecek

Dhananjaya Nauduri

Deliang Chen

Maria Estrella-Jimenez

Numan Oezguen

Venkatarajan S Mathura

Provided herein are analog and derivative compounds of inositol hexakisphosphate effective to treat ainfection and to neutralize the bacterial toxins produced by the same. In addition, methods of treating theinfection and for neutralizing its toxins with the compounds are provided.

Inositol hexakisphosphate analogs and uses thereof

Provided herein is a computational method for designing a PCP-consensus protein for a family of related proteins. The method uses a consensus alignment of a protein domain common to all the related proteins, which may or may not be substantially biased, from which an average value of p, e.g., 5, physicochemical properties are calculated for each amino acid in the alignment. The PCP-consensus protein has a sequence derived from an alignment of protein domains from a family of related proteins, said sequence containing one or more motifs common to all of the proteins. Also provided are the PCP-consensus proteins, kits comprising the same, datasets of aligned consensus sequences used to derive the PCP-consensus proteins and methods of eliciting an immune response, diagnosing or treating an infectious disease using the same.

Physicochemical (PCP) based consensus sequences and uses thereof

Fluorene-based molecules and their derivatives are described in compositions for the treatment of intestinal fluid loss.

Methods and compositions to inhibit edema factor and adenylyl cyclase

A data analysis system, program, and/or method, e.g., a data mining/data exploration method, using physical-chemical property motifs. For example, a sequence database may be searched for identifying segments thereof having physical-chemical properties similar to the physical-chemical property motifs.

Physical-chemical property based sequence motifs and methods regarding same

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Friendswood, TX, United States of America

Catherine Schein