Medtronic, Inc.

Medtronic Ablation Frontiers LLC

Medtronic Cryocath LP

Catherine R Condie

Mark T Stewart

Marshall L Sherman

Steven J Fraasch

Yong Kyun Cho

Trenton Jay Rehberger

William J Combs

John D Wahlstrand

Karen J Kleckner

John Charles Stroebel

Donald N Jensen

Boaz Avitall

Jay L Kelley

Qin Zhang

H Toby Markowitz

Daniel J Baxter

Kathryn Elaine Kasischke

Daniel J Greeninger

Robert W Stadler

Luc Roland Mongeon

Timothy J Corvi

Roy Christian Martin

Brian T Howard

Dwight H Warkentin

Sarah E Ahlberg

Aaron R Strunk

Louis Jacob

Paul S Lam

Gerald A Portzline

John S Brandstetter

Corinne Weyrauch

David L Thompson

Jeffrey M Gillberg

Jean-Pierre Lalonde

Bruce D Gunderson

Li Ping Wang

Troy Edward Jackson

Robert A Betzold

David Arthur Casavant

John C Rueter

Kevin T Ousdigian

Lee Stylos

Lucy M Nichols

James H Ericksen

Linda L Ruetz

Marilyn C Rochat

Nathan P Munsterman

Jon W Spence

Steve R Hornberger

Scott Davie

Ulla Strobel

Trento Jay Rehberger

John D Wahlstrandl

A method and system for mapping tissue and producing lesions for the treatment of cardiac arrhythmias in a non-thermal and optimal manner, minimizing the amount of energy required to selectively stun or ablate the target tissues. Energy may be delivered only at the moment(s) of best device position and proximity of an electrode to target tissue, and only during a time in the cardiac cycle determined to be optimal for reversible or irreversible effects. A method may include determining timing of the cardiac cycle and an optimal time within the cardiac cycle for energy delivery, evaluating proximity between at least one energy delivery electrode and the target tissue, and delivering pulsed field energy from the at least one energy delivery electrode to the target tissue when, during the optimal time for energy delivery, the at least one energy delivery electrode is in close proximity with the target tissue.

Timed energy delivery

A system and method for the safe delivery of treatment energy to a patient, which includes verification of system integrity before, during, or after the delivery of treatment energy and provides several mechanisms for rapid termination of the delivery of potentially harmful energy to the patient when a fault condition in the device and/or system is identified. The system may include an energy generator having processing circuitry to determine if there is a fault condition in the system and to automatically terminate a delivery of treatment energy when the processing circuitry determines there is a fault condition. The method may generally include performing a series of pre-checks, synchronizing a treatment energy delivery to the proper segment of the heart's depolarization pattern, configuring the system for treatment energy delivery, delivering the treatment energy, and performing post-treatment evaluation.

Methods of ensuring pulsed field ablation generator system electrical safety

Systems and methods to confirm safe delivery of treatment energy to a patient by identifying a presence of a fault in an energy delivery pathway and identifying a location of the fault within the device. The system includes a processing unit configured to calculate blood impedances external to the device based on known impedance characteristics of the device, and then to calculate impedances within the device during energy delivery based on the calculated blood impedances. The processing unit prevents the delivery of energy in an energy delivery pathway that is determined to be compromised. The processing unit is also configured to compare times for two different frequencies to travel a predetermined distance, the difference in the times corresponding to a location of a fault within the energy delivery pathway.

Method of confirming safe delivery pathway to patient prior to energy delivery

A cryoablation method, system, and device that allows for real-time and accurate assessment and monitoring of PV occlusion and lesion formation without the need for expensive imaging systems and without patient exposure to radiation. The system includes a cryoballoon catheter with a cryoballoon, a distal electrode, a proximal electrode, and a temperature sensor. Impedance measurements recorded by the electrodes may be used to predict ice formation, quality of pulmonary vein occlusion, and lesion formation.

Distal balloon impedance and temperature recording to monitor pulmonary vein ablation and occlusion

Methods and systems for combining ablation therapy with navigation of the ablation device. An ablation system may be configured for use with one of two methods to prevent loss of navigation signals during ablation energy delivery. In the first method, ablation energy signals are filtered from the navigation signal. In the second method, the delivery of ablation energy is sequenced with the delivery of navigation energy such that ablation energy and navigation energy are not delivered at the same time and navigation signals received by the system are time-division multiplexed to reconstruct the navigation signals and determine a location of the device within the patient.

Methods and systems to combine RF ablation therapy with device navigation

A method and system for assessing electrode-tissue contact before the delivery of ablation energy. The system may include a control unit programmed to determine a difference between a maximum impedance magnitude at a low frequency for a given electrode and an absolute minimum impedance magnitude at the low frequency across all electrodes, determine a difference between a maximum impedance magnitude at a high frequency for a given electrode and an absolute minimum impedance magnitude at the high frequency across all electrodes, and determine a difference between a maximum impedance phase at the high frequency for a given electrode and an absolute minimum impedance phase at the high frequency across all electrodes. Differences may be correlated to one another using a linear model, the results determining electrode-tissue contact status. The results may be displayed in a graphical format for easy communication to the user.

Tissue contact sensing with a multi electrode ablation catheter

A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; measuring a first impedance magnitude a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison.

Multi frequency and multi polarity complex impedance measurements to assess ablation lesions

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Shoreview, MN, United States of America

Catherine R Condie