Biomerieux, Inc.

Catherine Pothion

Florence Bettsworth

Sandrine Busseret

Béatrice Seigneres

A bi-epitope compound of formula I: in which: E1 and E2, identical or different, each separately represents a peptide sequence including at least one epitope of an analyte; X and Y, identical or different, each separately represents a linking arm, the carrier molecule is soluble and Z represents an amino acid derivative bearing a thiol function prior to the bonding of same with the carrier molecule. The compound may be contained in a composition, used as a control or standard in an immunoassay and associated method, and/or provided in a kit for implementing an immunoassay.

Synthetic bi-epitope compound

The invention relates to novel interfering peptides having peptide sequence S with between 7 and 12 amino acids, originating from the peptide sequence of an antigenic protein of a micro-organism M, the sequence S being aligned with a peptide sequence S' with between 7 and 12 amino acids originating from the peptide sequence of a target protein of a micro-organism M&#x2032; that is different from the micro-organism M, provided that: sequences S and S&#x2032; have at least 50% identity over their length of 7 to 12 amino acids and at least 4 identical or analogous contiguous amino acids; and their length is identical or they have 1 or 2 different amino acids distributed at one and/or the other end of the sequences. The invention also relates to a method for the in vitro immunoassay-based detection of the presence of a micro-organism M&#x2032; or M in a biological sample.

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Lyons, France

Catherine Pothion