Biomerieux, Inc.

Hospices Civils De Lyon

Catherine Ott

Bernard F Mandrand

Herve Perron

Francois Mallet

Frederic Bedin

Glaucia Paranhos-Baccala

Florence Komurian-Pradel

François Mallet

Geneviève Choquet-Kastylevsky

Mireille Sodoyer

Yasemin Ataman-Önal

Hader Haidous

Laurence Generenaz

Sandrine Michel-busseret

An isolated polynucleotide having a nucleotide sequence selected from the group consisting of (a) SEQ ID NO: 21, (b) the full-length sequences encoding a polypeptide having a peptide sequence selected from the group consisting of SEQ ID NOs: 25 and 26, and (c) the full-length complementary sequences to the sequences set forth in (a) or (b).

Isolated multiple sclerosis (MS)-associated retrovirus (MSRV) nucleic acids corresponding to the gag region

The invention concerns a nucleic material, in isolated or purified state, and a nucleotide fragment comprising a nucleotide sequence selected from the group consisting in (i) the sequences SEQ ID NO: 112, SEQ ID NO:114, SEQ ID NO: 117, SEQ ID NO: 120, SEQ ID NO. 124, SEQ ID NO: 130, SEQ ID NO: 141 and SEQ ID NO: 142, (ii) the complementary sequences of sequences (i); and (iii) the sequences equivalent to sequences (ii) and (iii), in particular the sequence having for every series of 100 contiguous monomers, at least 50%, preferably 70% homology with sequences (i) and (ii) respectively. The invention also concerns their uses for detecting a retrovirus associated with multiple sclerosis and/or rheumatoid arthritis.

Multiple sclerosis-associated retroviral (MSRV) nucleic acids corresponding to the Env region

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Lyons, France

Catherine Ott