University of Minnesota

Abt Holding Company

Katholieke Universiteit Leuven

Industry-University Cooperation Foundation Hanyang University

Healios K.k.

Mcl/llc

Institut D'investigacions Biomediques August Pi | Sunyer (idibaps)

Catherine M Verfaillie

Leo T Furcht

Morayma Reyes

Kartik Subramanian

Wei-Shou Hu

Jakub Tolar

Uma Lakshmipathy

Bruce Blazer

Pau Sancho-Bru

Karen Pauwelyn

Yonsil Park

Bruce Robert Blazar

Lucas Chase

Jianyi Zhang

Yves Pierre Heremans

Robert Gallegos

Michael Jerosch-Herold

Lepeng Zeng

Ruben Boon

Pau Sancho Bru

Mar Col Loperena

Luis Perea Sanchez

Bert Binas

Yuehua Jiang

Miguel Angel Barajas Velez

Valerie Roobrouck

Michel Delforge

The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.

Pluripotent cells derived from bone marrow and methods for isolation

The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other applications, for treatment of liver deficiencies, liver metabolism studies, and liver toxicity studies, fibrogenic studies, or to support hepatocyte function in co-culture setting.

Methods for differentiating cells into hepatic stellate cells

The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided.

Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof

The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.

Homologous recombination in multipotent adult progenitor cells

The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.

Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells

The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells.

Stem cell aggregates and methods for making and using

Multipotent adult stem cells and methods for isolation

The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype and cells that express a hepatic sinusoidal endothelial phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.

Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the method, and methods for using the cells

The present invention relates to methods for providing lysosomal enzymes to a subject by administering stem cells, preferably Multipotent Adult Progenitor Cells (MAPCs). The invention further relates to methods for treating lysosomal storage disorders by administering stem cells.

Compositions and methods for the treatment of lysosomal storage disorders

Growing community of inventors

Leuven, Belgium

Catherine M Verfaillie