Abbott Laboratories Corporation

Prometheus Laboratories Inc.

Catherine M Smith

Cynthia M Molina

Kenward S Vaughan

Janis A Martinus

Paul J Brynes

Esther H Oh

Paul J Byrnes

The present invention provides a method of diagnosing the presence or severity of tissue fibrosis in an individual by detecting &#x3b1;2-macroglobulin (&#x3b1;2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of tissue fibrosis in the individual based on the presence or level of &#x3b1;2-MG, HA and TIMP-1.

Methods of diagnosing tissue fibrosis

This disclosure relates to a method and reagents for determining amphetamine and methamphetamine in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determining the presence of amphetamine and methamphetamine in a single assay and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described includes pretreatment of the biological sample to eliminate cross-reactants such as .beta.-hydroxyphenethylamine by preincubating the sample solely with an aqueous periodate solution having a pH from about 4.0 to about 7.5 without adjustment to an alkaline pH.

Fluorescence polymerization immunoassay for amphetamine/methamphetamine

Fluorescence polarization immunoassay for amphetamine/methamphetamine

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Carlsbad, CA, United States of America

Catherine M Smith