Institut National De La Sante Et De La Recherche Medicale

Quantum Genomics

Centre National De La Recherche Scientifique

College De France

Other

Université Paris Descartes

Inserm

Catherine Llorens-Cortes

Bernard P Roques

Pierre Corvol

Fabrice Balavoine

Yannick Marc

Marie-Claude Fournie-Zaluski

Delphine Compere

Nicolas Inguimbert

Bernard Pierre Roques

Mathilde Keck

Solène E Boitard

Ji Gao-Desliens

Lionel Segard

Marie-Claude Fourni&eacute;-Zaluski

Solene E Boitard

The present invention relates to compounds, to compositions comprising the same, to methods for preparing the compounds, and the use of these compounds in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.

Compounds and compositions comprising the same for treating hypertension or heart failure

The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to a compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.

Aminopeptidase A inhibitors and pharmaceutical compositions comprising the same

The present invention relates to a pharmaceutical composition comprising, in at least one pharmaceutically acceptable support or vehicle, a combination of (3S,3S')4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) or a pharmaceutically acceptable salt or solvate thereof and a second active ingredient selected from the group consisting of angiotensin I converting enzyme inhibitors and angiotensin II receptor type I antagonists. Said composition is particularly useful for the treatment of hypertension and related diseases and conditions.

Combination of (3S,3S') 4,4&#x2032;-disulfanediylbis(3-aminobutane 1-sulfonic acid) and a second antihypertensive agent

The invention relates to derivatives of 4,4'-dithiobis-(3-aminobutane-1-sulfonates) of formula (1), of use for the treatment and prevention of primary and secondary arterial hypertension.

Derivatives of 4,4'-dithiobis-(3-aminobutane-1-sulfonates) and compositions comprising the same

The invention relates to the bis-hydrochloride of 4,4'-dithiobis-(3-aminobutane-1-sodium sulphonate) and the bis-trifluoracetate of 4,4&#x2032;-dithiobis-(3-aminobutane-1-sulphonate of 2,2-dimethylpropyl). The invention also relates to a pharmaceutical composition comprising one of said compounds and to the use of one of said compounds for the production of a medicament. The invention is suitable for use in a treatment method for hypertension and indirectly- or directly-linked illnesses.

Derivatives of 4,4'-dithiobis-(3-aminobutane-1-sulfphonates) and compositions containing same

The invention relates primarily to a pharmaceutical composition which can be used for lowering arterial blood pressure and is characterized in that it contains as active ingredient at least one selective aminopeptidase A inhibitor. Said inhibitor can notably be (S) 3-amino-4-mercaptobutyl sulfonic acid or one of its salts.

Pharmaceutical composition comprising at least one aminopeptidase A inhibitor

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Bures sur Yvette, France

Catherine Llorens-Cortes