Institut National De La Sante Et De La Recherche Medicale

Inserm (Institut National De La Sante Et De La Recherche Medicale)

Inserm

Catherine Harb

Yannick Jacques

Erwan Mortier

Agnès Quemener

Ariane Plet

Jérôme Bernard

The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor &#x3b1;-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (LLELQVISL, peptide 1) corresponds to a sequence located in the B helix and the second (ENLII, peptide 2 orENLIIL, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.

IL-15 mutants having antagonist activity

The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor &#x3b1;-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (LLELQVISL, peptide 1) corresponds to a sequence located in the B helix and the second (ENLIL, peptide 2 orENLIIL, peptide 2) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.

IL-15 mutants having agonists/antagonists activity

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Nantes, France

Catherine Harb