Institut Pasteur

Centre National De La Recherche Scientifique

Catherine Gouyette

Jean Igolen

Tam Huynh Dinh

Luc Montagnier

Francoise Barre-Sinoussi

Jean-Francois Nicolas

Robert M Fauve

Yvette Henin

Bernadette Dupraz

Olivier Schwartz

Nathalie Savatier

A compound having the following formula I: ##STR1## in which: R' represents a hydrogen atom or an azido group,

Glucosyl phosphotriesters of thymidine

The glycosylphospholipid nucleoside derivatives of the invention are based on the formula: ##STR1## wherein: R.sub.1 is a nucleoside derivative selected from the group consisting of 3'-azidothymidine (AZT); 2', 3'-dideoxythymidine (ddT); and 2'-deoxy-5-fluorouridine (dFU);

Glycosyl phospholipid derivatives of nucleosides and their use as

The invention concerns 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine nucleosides in which the sugar component is substituted at position 3' or position 5' by a phosphite or phosphoramidite group of the formula: ##STR1## R.sub.1 representing a lower alkyl or --(CH.sub.2).sub.n --CN with n being an integer between 1 and 4, and X representing a halogen or an amine group. These nucleosides make it possible to prepare sequences of nucleotides usable, in particular, as probes in the field of analyses and biological extractions.

2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted

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Catherine Gouyette