Hoffmann-la Roche Inc.

Roche Molecular Systems, Inc.

Eastman-kodak Company

Catherine E Greer

M Michele Manos

Robert M Resnick

Heidi M Bauer

Yi Ting

Patti E Gravitt

Allan D Pronovost

John C Mauck

Sheryl S Sullivan

James H Gilbert

Tracy Y Zhang

Tracy Yi Zhang

Chaka C Impraim

The presence of human papillomavirus (HPV) in a sample can be detected and the HPV typed by a method that involves the amplification of HPV DNA sequences by the polymerase chain reaction (PCR). The primers used in the method are consensus primers that can be used to amplify a particular region of the genome of any HPV. The presence of HPV in a sample is indicated by the formation of amplified DNA. The HPV nucleic acid is detected by consensus probes that may be short oligonucleotide probes or long generic probes. The HPV is typed by the use of type-specific DNA probes specific for the amplified region of DNA.

Detection of human papillomavirus by the polymerase chain reaction using

Detection of human papillomavirus by the polymerase chain reaction

The presence of human papillomavirus (HPV) in a sample can be detected and the HPV typed by a method that involves the amplification of HPV DNA sequences by the polymerase chain reaction (PCR). The primers used in the method are consensus primers that can be used to amplify a particular region of the genome of any HPV. The presence of HPV in a sample is indicated by the formation of amplified DNA. The HPV nucleic acid is detected by consensus probes that may be short oligonucleotide probes or long genetic probes. The HPV is typed by the use of type-specific DNA probes specific for the amplified region of DNA.

An extraction composition is useful for lysing chlamydial, gonococcal or herpes organisms and extracting detectable antigen from the organisms. In particular, this composition has a high pH (at least about 8) and comprises an alcoholamine which is effective in extracting antigen. It is particularly useful for extracting either or both of the lipopolysaccharide and major outer membrane protein chlamydial antigens.

High pH extraction composition and its use to determine a chlamydial,

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Oakland, CA, United States of America

Catherine E Greer