Aventis Pharma S.a.

Rhone-poulenc Rorer S.a.

Catherine Dubertret

Daniel Scherman

Gerardo Byk

Jean-Paul Martin

Jean Leboul

Bertrand Schwartz

Jean-Jacques Debernard

Bruno Pitard

G&eacute;rardo Byk

Gerard Helynck

The invention concerns a novel agent for transferring nucleic acids into cells. Said agent is particularly characterised in that it comprises one or several disulphide bonds sensitive to reducing conditions. The invention also concerns compositions comprising such an agent for transferring in vivo, ex vivo or in vitro nucleic acids of interest into different cell types.

Transfecting compounds which are sensitive to reducing conditions, pharmaceutical compositions containing them and their applications

The invention concerns compounds for transferring nucleic acids into cells. The compounds are more particularly related to the lipopolyamine family, and comprise amidine functions. The compounds are useful for transferring nucleic acids of interest into various cellular types, in vitro, in vivo, or ex vivo.

Compounds, preparation and use for transferring nucleic acids into cells

Lipopolyamines useful for the transfection of nucleic acid and methods of preparation thereof are disclosed. The lipopolyamines are of general formula I, in which R4 comprises at least one C10-C22 aliphatic radical.

Lipopolyamines as transfection agents and pharmaceutical uses thereof

Lipopolyamines as transfection agents and pharamaceutical uses thereof

Intermediates of peptide antagonists of neurotensin

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Sevres, France

Catherine Dubertret