Ludwig Institute for Cancer Research Limited

Departemente D'immunologie Institut Henri Beaufour

Department D'immunologie Institut Henri Beaufour

Catherine Druez

Jacques Van Snick

Jean-Christophe Renauld

Catherine Uyttenhove

Pierre G Coulie

Pierre Braquet

Bernard Dugas

Jean M Mencia-Huerta

The invention describes nucleic acid sequences which code for the interleukin 9 receptor (IL9-R) molecule. These sequences may be used as probes to identify cells expressing the molecule, and as agents to transfect recipient cells.

Methods for producing antibodies which specifically bind to

Nucleic acid sequences coding for or complementary to nucleic acid

A method for inhibiting production of IgE, and a method for enhancing production of IgG are taught. The methods are linked to the role of interleukin 9 in antibody production. Specifically, production of IgG is potentiated by administering either to a subject or a cell culture a combination of interleukin 4 and interleukin 9. Production of IgE is inhibited by administering an amount of an interleukin 9 inhibitor to a subject.

Method for inhibiting production of IgE by using IL-9 inhibitors

The invention relates to substantially pure interleukin 9 receptor molecules and the use thereof. The uses include use as an interleukin-9 inhibitor, as a diagnostic agent for determining interleukin-9, and as a screening agent for pharmaceuticals. The interleukin-9 receptor is characterized as a glycoprotein of about 64 kilodaltons which, upon digestion with N-glycosidase F, yields a peptide of about 54 kilodaltons.

Uses of substantially pure interleukin-9 receptor

Method for inhibiting production of IGE and method for enhancing

The invention relates to substantially pure interleukin 9 receptor molecules and the use thereof. The uses include use as an interleukin-9 inhibitor, as a diagnostic agent for determining interleukin-9, and as a screening agent for pharmaceuticals. The interleukin-9 receptor is characterized as a glycoprotein of about 94 kilodaltons which, upon digestion with N-glycosidase F, yields a peptide of about 54 kilodaltons.

Substantially pure interleukin-9 receptor and uses thereof

Growing community of inventors

Sint-Stevens-Woluwe, Belgium

Catherine Druez