Sanofi

Catherine Devaud

Seng H Cheng

Ercole Rao

Christian Lange

Yunxiang Zhu

William Harold Brondyk

Ronnie Rong Wei

Timothy D Connors

Christian Beil

Catherine Prades

Hongmei Zhao

Yangde Chen

Dietmar Hoffmann

Maureen Magnay

Tristan Magnay

Leila Sevigny

Bruno Dumas

Nabil Lounis

Ronnie Wei

Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.

Multispecific binding molecules having specificity to dystroglycan and laminin-2

The present invention is within the field of industrial protein production. The inventors have designed and constructed a new expression system comprising an expression vector coding for a glutamine synthetase of human or dog origin, and a CHO cell line. More specifically, the invention pertains to a combination of (i) a DNA vector suitable for production of a recombinant protein, wherein said vector comprises a sequence coding for a glutamine synthetase, and (ii) a Chinese Hamster Ovary (CHO) cell line, wherein said GS comprises a sequence at least 94.5% identical to the sequence of SEQ ID NO: 1 or to the sequence of SEQ ID NO: 2.

CHO expression system

Growing community of inventors

Malakoff, France

Catherine Devaud