Centre National De La Recherche Scientifique

Institut Gustave Roussy

Université De Versailles—saint-quentin-en-yvelines

Mitologics

Université Versailles Saint-quentin-en-yvelines

Catherine Brenner

Jean-Christophe Cintrat

Eric Deutsch

Etienne Jacotot

Frederic Taran

Annie Borgne-Sanchez

Jean Luc Perfettini

Frédéric Taran

The present invention is drawn to the use of Minaprine dihydrochloride and analogs thereof, for reducing tumor growth when administered to a patient suffering from cancer.

Use of minaprine to reduce tumor growth

The present invention is drawn to the use of the compounds highlighted in Tables 1 & 2 and analogs thereof, for enhancing IR-mediated cellular cannibalism in cancer cells. Said compounds are herein called 'enhancers of IR-mediated cellular cannibalism'. They can be used to enhance tumor immunogenicity and/or to induce a significant protective anticancer immune response in subjects that will receive or that have received a radiotherapy treatment. In other words, said compounds can be used to potentiate a radiotherapy treatment in a subject in need thereof. Said compounds are preferably chosen in the group consisting of: Mebhydroline 1,5-napthalene disulfonate salt, Flurbiprofen, Minaprine dihydrochloride, Myricetin, Digoxin, Digitoxin, Lanatoside, LOPA87, VP331, RN-1-026, SG6163F, VP450, and VP43.

Enhancers of cellular cannibalism for use to sensitize tumors to radiation therapy

ANT-ligands having a substituted nitrogeneous heterocycle A wherein wherein wherein wherein,Ar and R2 are as above defined with respect to formula I.

Ant-ligands molecules and biological applications

The invention relates to molecules ANT-ligands having a substituted nitrogeneous heterocycle A wherein wherein wherein wherein,Ar and R2 are as above defined with respect to formula I.

ANT-ligands molecules and biological applications

Growing community of inventors

Le Chesnay, France

Catherine Brenner