Astrazeneca Ab

Catherine Boissier

Anne Mari Juppo

Anette Larsson

H&aring;kan Glad

Marie-Louise Andersson

A method of preparing drug particles of a substance which are susceptible to degradation by the use of a fluid gas technique.

Method of producing drug particles

The present invention relates to a method for forming particles of a substance, comprising the step of introducing into a mixing chamber ( ), in which the temperature and pressure are controlled, a fluid gas ( ) and at least one vehicle system ( ) comprising at least one substance in solution or suspension such that droplet formation and extraction of the vehicle occur substantially simultaneously by the action of the fluid gas ( ). Turbulence is induced in at least one of said fluid gas ( ) and said vehicle system ( ) so as to create a controlled disorder in the flow of the at least one of the fluid gas ( ) or the vehicle system ( ) in order to control the particle formation in said mixing chamber ( ), said controlled disorder being created by at least one flow perturbation means ( ). The invention also relates to a mixing chamber having at least one flow perturbation means ( ) that is disposed for interacting with at least one of a fluid gas ( ) or vehicle system ( ) supplied by the at least one supply member ( ) so as to induce turbulence or limited disorder in the at least one of the fluid gas ( ) or vehicle system ( ).

Method and device for forming particles

A process for the incorporation of an active substance in a carrier system by forming an emulsion of the components and precipitating the system by the use of fluid gas technique.

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Göteborg, Sweden

Catherine Boissier