Esbatech Ag

Oncalis Ag

Catherine Berset

Tea Gunde

Alcide Barberis

Andreas Schumacher

Julia Tietz

Stephan Audetat

Peter Traxler

Andreas c/o Solvias Ag Schumacher

An in vivo method for the identification and/or validation of receptor tyrosine kinase inhibitors is described. Said method is characterized by the following steps: providing host cells comprising a nucleic acid construct encoding a peptide which comprises a tyrosine kinase domain of a receptor tyrosine kinase wherein said peptide lacks a transmembrane domain or a functional fragment thereof and said tyrosine kinase activity in the cytoplasma leads to proliferation arrest, contacting said host cells with a candidate compound and identification of inhibitors of said tyrosine kinase activity by cultivation of said host cells under suitable conditions such that the modulation of the tyrosine kinase activity by the candidate compound leads to cell growth.

Method for the identification and/or validation of receptor tyrosine kinase inhibitors

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Windisch, Switzerland

Catherine Berset