Divergence, Inc.

Catherine Baublite

Deryck Jeremy Williams

Andrew P Kloek

Michelle Coutu Hresko

Jennifer A Davila-Aponte

Merry B McLaird

Rodolfo Zentella

Michelle L Verbsky

John D Bradley

SiQun Xu

Anita M Frevert

Brandi J Chiapelli

Michelle L Gasper

The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues.

Method for screening transgenic plants for anthelmintic activity

The present invention provides a method of screening transgenic plants containing a DNA construct encoding a polypeptide that when expressed in the plant results in the production of fatty acid compounds for anthelmintic activity by contacting the plants with a plurality of nematodes.

Method of screening transgenic plants for anthelmintic activity

The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.

Nucleic acids encoding anthelmintic agents and plants made therefrom

Transgenic plants having anthelmintic activity and methods of producing them

Nucleic acid molecules from nematodes encoding PAN and ZP domain containing receptor polypeptides are described. PANZP polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PANZP nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.

Nematode PAN and ZP receptor-like sequences

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St. Louis, MO, United States of America

Catherine Baublite