New Jersey Institute of Technology

Friedrich-Alexander-Universitat Erlangen-Nürnberg

Catharina Knieke

Rajesh N Dave

Thomas Koch

Daniel To

Ecevit A Bilgili

Wolfgang Peukert

Mohammed A Azad

Christian Roßkopf

Angela Berger

Michael Voigt

A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.

Pharmaceutical core-shell composite powder and processes for making the same

Growing community of inventors

Ludwigshafen, Germany

Catharina Knieke