Innocore Technologies B.v.

Polyganics Bv

Stryker European Holdings I LLC

Stryker European Operations Holdings LLC

Catharina Everdina Hissink

Theodorus Adrianus Cornelius Flipsen

Johan Zuidema

Rob Steendam

Linda Joan Gibcus

Ronald Meyboom

Theodorus Adrianus Flipsen

Hans Wicher Kuijper

Theodorus Adrianus C Flipsen

Theodorus Flipsen

The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O—groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.

Biomedical foams

The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises &#x2014;C(O)&#x2014;O&#x2014; groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.

The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used, e.g., in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer comprises &#x2014;C(O)&#x2014;O&#x2014; groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.

The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.

Biodegradable multi-block co-polymers

The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. According to the invention, a biodegradable, phase separated copolymer is provided, comprising segments of a soft prepolymer (A) having a glass transition temperature, Tg, lower than 37&#xb0; C.; and segments of a hard prepolymer (B) having a phase transition temperature, Tm, of 40-100&#xb0; C.

Biodegradable phase separated segmented multi block co-polymers

The present invention relates to specific DL-lactide-&#x3b5;-caprolactone copolymers and the application of these polymers in the production of biodegradable medical applications. According to the present invention a polymeric material comprising poly(DL-lactide-co-&#x3b5;-caprolactone) is provided, which is obtained by the copolymerization of DL-lactide and &#x3b5;-caprolactone, having a lactide content of 51-75 mol %, most preferably of 62-69 mol %.

DL-lactide-&#x3b5;-caprolactone copolymers

The invention relates, generally, to medical appliances. More particularly, it relates to tubular shaped devices used as drains for draining fluids (liquids and/or gases) from antrums or other parts of the human or animal body. According to the present invention a drain is provided, which is suitable for draining a human or animal antrum, which drain comprises a synthetic biodegradable material, preferably a biodegradable polymer.

Biodegradable drains for medical applications

The present invention relates to specific DL-lactide-&#x3b5;-caprolactone copolymers and the application of these polymers in the production of biodegradable medical applications. According to the present invention a polymeric material comprising poly(DL-lactide-co-&#x3b5;-caprolactone) is provided, which is obtained by the copolymerization of DL-lactide and &#x3b5;-caprolactone, having a lactide content of 51-75 mol %, most preferably of 62-69 mol %. The materials of the present invention have excellent mechanical properties and may be used to provide articles for medical application, in particular nerve guides.

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Groningen, Netherlands

Catharina Everdina Hissink