University of California

Vybyl Holdings, Inc.

Elevance Renewable Sciences, Inc.

Cassandra E Callmann

Paul A Bertin

Nathan C Gianneschi

Clare L M LeGuyader

Matthew P Thompson

The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.

Growing community of inventors

San Diego, CA, United States of America

Cassandra E Callmann