The University of Texas System

Casey Pirnstill

Gerard L Cote

John Philip Hanks

Bilal H Malik

Daniel T Grunden

Erwin Thomas, Iii

Embodiments concern coupling polarized light at two or more wavelengths across the aqueous humor of the eye (e.g., as part of a noninvasive glucose monitoring system). An approach discloses non-contact and minimal contact eye-coupling designs that are part of a system for providing glucose concentration levels via measurements acquired by passing two or more optical beams through the cornea/aqueous chamber in the eye. The approach provides for coupling the light to account for the index mismatch incurred while allowing for monitoring the light polarization. Specifically, in an embodiment the light transitions from the device, through the air, through the proximal side of the cornea, through the aqueous humor, through the medial side of the cornea, and through the air back into the device. Embodiments address the index of refraction mismatch and polarized light maintaining concerns with a coupling approach that can take the form of contact and non-contact mechanisms.

Eye coupling mechanism for noninvasive glucose measurements with polarized light

An embodiment relates generally to an improved method and apparatus for modulating the amplitude and rotation of the plane of polarization of linearly polarized light for multiple uses but primarily as part of a noninvasive glucose monitoring system. As compared to previous monitoring systems, an embodiment provides faster monitoring while maintaining or even reducing noise and minimizing system complexity. Embodiments described herein address these concerns with a modulation and compensation approach that both uses a single high speed device and also modulation of the lasers.

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Bucyrus, OH, United States of America

Casey Pirnstill