Johnson & Johnson Medical Gmbh

Johnson & Johnson Gmbh

Cary B Linsky

Timothy J Cunningham

Lowell G Saferstein

Stephen J Wolf

David M Wiseman

David T Rovee

Lola Kamp

Oxidized cellulose material is neutralized, by contacting an acidic oxidized cellulose material with a water and alcohol solution of a basic salt of a weak organic acid, e.g. sodium acetate, to elevate the pH of the cellulosic material to between 5 and 8. The resulting neutralized product is storage stable and has therapeutic applications, including hemostasis and adhesion prevention. Furthermore, the neutralized product may be impregnated with acid-sensitive hemostatic agents, such as thrombin, to enhance its hemostatic properties, or with acid-sensitive adhesion-preventive agents, such as t-PA, to enhace its adhesion-prevention properties.

Process for preparing a neutralized oxidized cellulose product and its

An absorbable fabric which effectively reduces the incidence of postoperative adhesions when used as a physical barrier at the operative site is a warp knit fabric of oxidized regenerated cellulose or other bioresorbable material. The barrier fabric is particularly characterized by having a density of 8 to 15 mg/cm.sup.2 and an open area porosity of 12 to 20 percent.

Method and material for prevention of surgical adhesions

An absorbable fabric which effectively reduces the incidence of postoperative adhesions when used as a physical barrier at the operative site is a warp knit fabric of oxidized regenerated cellulose or other bioresorbable material. The barrier fabric is particulary characterized by having a density of 8 to 15 mg/cm.sup.2 and an open area porosity of 12 to 20 percent.

A non-occlusive, non-adherent dressing for wounds, the dressing comprising an imperforate (i.e. continuous) flexible film for contacting the wound, and an absorbent pad backing the wound-contacting film and extending beyond a substantial portion of the periphery of the film, the dressing having vapor transport cavity approximating that of intact human skin. The absorbent pad removes wound exudate from the proximate area of the wound without the pad coming into contact with the open wound itself. The final construction, comprising the film and absorbent backing, permits a measurable amount of moisture vapor to be transmitted (greater than 0.06 mg/cm.sup.2 /hr), thereby greatly reducing the degree of maceration and other problems that may be produced by a fully occlusive dressing.

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East Brunswick, NJ, United States of America

Cary B Linsky