University of Minnesota

Science & Technology Corporation & Unm

Tychon Bioscience, LLC

Carston R Wagner

George W Griesgraber

Richard Smith Larson

Benjamin Joseph Hackel

Lawrence Arthur Stern

Aniekan Okon

Clifford Csizmar

Jae Chul Lee

Rachit Shah

Sidath C Kumarapperuma

DaQing Yang

Described herein are small molecule cap-dependent inhibitors, including the compound of the formula: which compounds that can induce the accumulation of the p53 tumor suppressor protein in cancer cells that still express wild-type p53, as well as methods of using those compounds to, among other things, treat neuroblastoma, pediatric glioblastoma multiforme or breast cancer.

Pharmaceutical compounds and uses thereof

Certain embodiments of the invention provide epithelial cell adhesion molecule (EpCAM) binding polypeptides, as well as conjugates and CSANs comprising such polypeptides. Additionally, certain embodiments of the invention also provide methods of using such polypeptides and compounds for molecular imaging and molecularly targeted therapies.

EpCAM targeted polypeptides, conjugates thereof, and methods of use thereof

Embodiments provide, among things, compounds of the formula I: wherein Het, Y, R, Z, X, R-R, R, and Rare defined herein; and methods for using such compounds to reduce pain (e.g., neuronal pain), treat a mammal's addiction to nicotine or anti-pain drugs, and increase a mammal's sensitivity to drugs that bind MOR or NMDAR.

Sulfamide and sulfamate inhibitors of hHint1

Provided herein are compounds, conjugates and methods for making lipid-chemically self-assembled nanorings (Lipid-CSANs) and using them to treat diseases and modify cell surfaces.

Methods of making and using chemically self assembled-nanorings

The invention provides methods for attaching drugs, dyes or radiolabels to bis-MTX. This method can be used to prepare bis-MTX analogs that can be used to deliver agents, such as nanoparticles, drugs, dyes or radiolabels, to cells.

Methods of making and using nanostructures

The invention provides a compound of formula (I), wherein R-Rand X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.

Nucleosides with antiviral and anticancer activity

The invention provides a compound of formula (I), wherein R1-R6 and X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.

The invention provides protein nanorings.

Protein nanorings

The invention provides a compound of formula (I), wherein R-Rand X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds. 

The invention provides isolated nucleic acid sequences encoding polypeptides having nucleoside phosphoramidase activity, and methods of screening for nucleoside phosphoramidate compounds that are cleaved by a phosphoramidase or for phosphoramidases that are able to cleave phosphoramidate compounds. The invention also provides methods of delivering a nucleoside monophosphate.

Nucleoside phosphoramidates and nucleoside phosphoramidases

The present invention provides a compound and a method of making a compound according to the following formula:where Ris an alkyl group having 1 to 12 carbons; Ris a urea group; Ris an active group, such as fluorescein, a toxin, radiolabel or drug; and R, Rand Rare each independently a halide group.

Small molecules for inhibition of function and drug delivery to leukocytes

The invention provides nucleosides of formulae (I), (II), (V) and (VII) as described in the specification which possess antiviral and anticancer activity. Treatment of breast cancer is a preferred embodiment.

Growing community of inventors

Saint Paul, MN, United States of America

Carston R Wagner