Eli Lilly and Company

Abb Vie Deutschland Gmbh & Co. Kg

Abbvie Biotechnology Ltd

Friedrich-Alexander-Universitat Erlangen-Nürnberg

Carsten Weber

Tong Zhu

Wolfgang Fraunhofer

Susan K Paulson

Susan Marie Reutzel-Edens

Markus Tschoepe

David Scott Coffey

Steven Wayne Pedersen

Hans-Jürgen Krause

Carsten Timpe

Shella Lenyonga Tameze

Pamela Kaye Footman

Alfio Borghese

Sonja Simon

Alexander Feick

Martin Gastens

Laura Redden

Michael Neu

The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof.

High concentration anti-TNF&#x3b1; antibody liquid formulations

The present invention concerns a method and a device for determining mechanical stress load, and optionally interface effects, on particles dispersed in a fluid. According to the invention, fluid comprising dispersed particles such as biomolecules is fed into a sample space of a device comprising a jacket which encloses a sample chamber and at least two rolls arranged within said jacket such that said sample space is defined between said rolls, said rolls being independently rotatable with respect to each other, wherein said jacket has an inner surface which is essentially adapted to the outer surface of the rolls, rotational movement is imparted to at least one of the rolls of said device, and changes in the state of said particles are determined from which mechanical stress load acting on the particles can be determined.

Method and device for determining mechanical stress load and interface effects on particles dispersed in a fluid

The present invention provides novel crystalline forms of {2-[1-(3,5-bistrifluoromethylbenzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, compositions thereof, intermediates thereof, methods of using the same, processes for making the same, and processes for making intermediates thereof.

Crystalline forms of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone

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Maxdorf, Germany

Carsten Weber