Eisai R&d Management Co., Ltd.

Carsten T Beuckmann

Toshiaki Tanaka

Taro Terauchi

Takashi Doko

Yu Yoshida

Yoshimitsu Naoe

Keiichi Sorimachi

Yuji Kazuta

Margaret Moline

Kodo Shikata

Ayumi Takemura

Toru Sawai

Andrew Satlin

Michiyuki Suzuki

Methods of treating irregular sleep-wake rhythm disorder in subjects and compositions for use in the same are disclosed.

Methods of treating circadian rhythm sleep disorders

A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents &#x2014;CH&#x2014; or a nitrogen atom, Rand Reach independently represent a Calkyl group and the like, Rrepresents a hydrogen atom and the like, R, R, Rand Reach independently represent a hydrogen atom, a halogen atom, a Calkyl group and the like, R, Rand Reach independently represent a hydrogen atom, a halogen atom and the like, and Rrepresents a hydrogen atom and the like.

Cyclopropane compound

An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.

Method of screening for antianxiety drugs

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Ibaraki, Japan

Carsten T Beuckmann