Bayer Aktiengesellschaft

A. Nattermann & Cie Gmbh

Carsten Materne

Hans Betzing

Jurgen Biedermann

Volker Neuser

The invention relates to dihydropyridine compounds of formula (I) as defined in the specification, containing a hetero-ring substituent in the 4-position. Also included in the invention are pharmaceutical compositions containing said compounds of formula (I) and methods for the use of said compounds and compositions. The said compounds are useful for influencing circulation.

Dihydropyridine compounds which are substituted in the 4-position by

The invention relates to 1,4-dihydropyridines which carry an arylalkyl or aryloxyalkyl radical in the 4-position. Also included in the invention are methods for the preparation of said compounds. The invention further relates to compositions containing said 1,4-dihydropyridines and the use of said compounds and compositions for their circulation influencing effects.

Certain 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylates,

The invention relates to 1,4-dihydropyridine-4-carboxylic acid amines of the formula (I) as defined in the specification. Also included in the invention are methods for the preparation of said compounds. The invention further relates to compositions containing said 1,4-dihydropyridines and the use of said compounds and compositions for their circulation influencing effects.

1,4-Dihydropyridine-3,5-dicarboxylate-4-carboxamide compounds,

2-Oxo-1-pyrrolidinylalkylcarboxylic acid amides of formula I ##STR1## in which R represents a hydrogen atom or hydroxy group, R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents a substituted or unsubstituted pyridyl group or a substituted phenyl group, the substitution being by from 1 to 3 substituents, which may be the same or different selected from halogen atoms, trifluoromethyl, nitro and acetyl groups, straight or branched-chain alkyl groups having 1-4 carbon atoms, alkoxy groups having 1-4 carbon atoms, straight or branched-chain alkylmercapto groups having 1-7 carbon atoms, substituted alkylmercapto groups of the general formula II ##STR2## in which n represents 1 or 2, R.sub.3 is a hydrogen atom or a methyl group and R.sub.4 is a hydroxy group or an amino group of the general formula V ##STR3## in which R.sub.8 represents a hydrogen atom or methyl group and R.sub.9 represents a methyl group or substituted or unsubstituted benzyl group, or R.sub.8 and R.sub.9 together with the nitrogen atom shown in formula V, form a substituted pyrrolidine ring; sulphonyl groups of the general formula III

Pyrrolidinylalkylcarboxylic acid amide derivatives, their preparation

The present invention is related to the new 2.6-dimethyl-4-(3'-nitrophenyl)-1.4-dihydropyridine-3-carboxylic acid beta-trimethylsilylethyl ester-5-carboxylic acid lower alkyl esters with improved antihypertensive and to a process for the treatment of humans suffering from hypertension with such compounds.

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Bonn, Germany

Carsten Materne