Novo Nordisk A/s

Leo Pharmaceutical Products Ltd. A/s

Carsten Lund

Niels Frederik Keiser-Nielsen

Erik T Hansen

Gunnar Monrad Sie

Helene Juhldal Knopper

The present invention relates to methods and devices for providing a reduced risk of free flow from medical devices such as an infusion pump. A medicament containing reservoir is provided with a piston having a sealing portion formed by a material of a first stiffness. The piston further comprises a frictional enhancing member having one or more reservoir wall engaging portions and being at least partly made of a material having a stiffness greater than the first stiffness. By arranging the frictional enhancing member to exert a radially outwards directed force component against the cylindrical wall an increased friction is provided between the piston and the reservoir wall.

Fluid infusion system, a method of assembling such system and drug reservoir for use in the system

The present application relates to methods and devices for providing a reduced risk of free flow from medical devices such as an infusion pump. A medicament containing reservoir () is provided with a piston having a sealing portion () formed by a material of a first stiffness. The piston further comprises a core member () of a material having a stiffness larger than said first stiffness, the core member comprising one or more connective members () being adapted to cooperate with said one or more protrusions of the linear actuation member. The one or more connective members being adapted to be substantially rigid in the axial direction while being resilient in a radial direction, thereby forming a releasable snap or friction fit connection with the linear actuation member. Thereby a mechanism is provided which is engageable by a purely axial relative displacement and which is disengageable by retracting the linear actuation member axially relative to the piston by exerting a pulling force greater than a predetermined limit.

A container ( ) for a hypodermic syringe ( ) and of the type which allows it to be seen or observed in another manner that the container has been opened. The container ( ) comprises a plug ( ) having more than one tamper-proof mechanism. This ensures both that the hypodermic syringe ( ) can reach the user in a state which allows it to be seen whether it has been opened, and that, after use, it can be disposed of in such a state that re-use is impeded considerably.

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Vordingborg, Denmark

Carsten Lund