Other

Forschungszentrum Julich Gmbh

Heinrich-Heine-Universität

Mueller-Schiffmann, Andreas

Petsch, Benjamin

Korth, Carsten

Stitz, Lothar

Carsten Korth

Andreas Mueller-Schiffmann

Peter Gmeiner

Ralf Klingenstein

S Rutger Leliveld

Stefan Löber

Sirik Rutger Leliveld

Andreas Müller-Schiffmann

Lothar Stitz

Sirik Leliveld

Rutger Leliveld Sirik

Dieter Willbold

Susanne Aileen Funke

Verian Bader

Kateryna Kravchenko

Laura Hecher

Aileen Funke

Steffen HÜBINGER

Svenja Trossbach

The invention relates to an antibody, antibody fragment or derivative thereof which specifically recognizes a prion protein and which comprises a complementarity determining region (CDR), a retro-inverso D-peptide of said CDR and/or an anti-idiotypic antibody, antibody fragment or derivative thereof which recognizes said CDR. The invention further concerns a nucleic acid molecule encoding said antibody, antibody fragment or derivative thereof as well as a method for generating an antibody, antibody fragment or derivative thereof that specifically recognizes a prion protein, wherein an antibody that recognizes a specific domain of the prion protein is generated, an antigen-specific amino acid sequence is isolated from said antibody, and an anti-idiotypic antibody, antibody fragment or derivative thereof, which recognizes said antigen-specific amino acid sequence, is generated.

Anti-prion protein antibody fragment

The invention relates to compounds according to general formula (1) and/or their enantiomers, diastereomers as well as their pharmaceutically compatible salts, and to the use thereof for producing a medicament suited for treating diseases associated with misfolded proteins.

9-amino-acridine derivatives and their use for eliminating misfolded proteins

An antibody for diagnosis or treatment of neuropsychiatric diseases, in particular schizophrenia, depression or bipolar affective disorders, is characterized in that the antibody recognizes misfolded specific proteins that can be assigned to one of the diseases, and a method for diagnosis by means of antibodies that bind to neuropsychiatric disease-specific proteins.

Antibody for diagnosing neuropsychiatric diseases, in particular schizophrenia, depression and bipolar affective disorders

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Dusseldorf, Germany

Carsten Korth