Novo Nordisk A/s

Carsten Jessen

Birgitte Schjellerup Wulff

Soeren Oestergaard

Birgit Wieczorek

Kilian Waldemar Conde Frieboes

Jens Kaalby Thomsen

Annika Sanfridson

Birigtte Schjellerup Wulff

Søren ØStergaard

The invention relates to PYY compounds having the amino acid in the position corresponding to position 30 of hPYY(1-36) substituted with tryptophan and derivatives thereof with a modifying group attached to the position corresponding to position 7 of hPYY(1-36). The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY compounds and pharmaceutically acceptable excipients, as well as the medical use of the PYY compounds.

Selective PYY compounds and uses thereof

The invention relates to PYY compounds with the amino acid modifications 7Lys, 30Trp, and 31Leu, and in addition to these, 22Ile and/or 28Tyr, and derivatives thereof. The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY compounds and pharmaceutically acceptable excipients, as well as the medical use of the PYY compounds.

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Birkeroed, Denmark

Carsten Jessen