Protein Technologies, Inc.

Institute Fuer Diagnostik Forschung

Insitut F&uuml;r Diagnostikforschung Gmbh

Carsten Hessenius

Kai Licha

Wolfhard Semmler

Rudolf Volkmer-Engert

Andreas Becker

Bertram Wiedenmann

Jens Schneider-Mergner

Volker Johannson

Oliver Johannes Kreuzer

Ralph-Th Roeder

Carsten Grotzinger

This invention relates to an apparatus for simultaneously carrying out multiple and highly parallel synthesis of compounds based on the solid-phase synthesis technique, in particular, peptide synthesis. Time-consuming and costly multiple rinsing processes required in solid-phase synthesis after distributing and replacing the reagents can be avoided by proposing an improved apparatus for fully automatic synthesis and subsequent separation of the synthesized compounds that involves separate synthesizer pinsfor each synthetic unit with a reagent reservoirand individual dosing capability. These synthesizer pinsare provided in a separate holderfrom where they are picked up by the gripper armof the automatic synthesizer. The openings of the reaction chambersof the synthesizer platesare closed (covered) by a permeable materialfor contamination-free placement of the synthesizer pinsand adding reagent doses to the solid or liquid phases. In addition, a sample platethat collects the samples dissolved after separation is provided underneath the valve block(see FIG.).

Device for simultaneous multiple and high parallel synthesis

The description herein includes cyanine dyes and analogs of the vaso-active intestinal peptide. These are useful to provide peptide-dye conjugates for use as contrast media in optical diagnoses.

Short-warp peptide-dye conjugate as contrast agent for optical diagnostic

The invention relates to compounds for tumor diagnosis that consist of conjugates of dyes with short-chain peptides, which are derived from vaso-active intestinal peptide, somatostatin or neurotensin, the use of these compounds as optical dignostic agents, and diagnostic agents that contain these compounds.

Short-chain peptide-dye conjugates as contrast media for optical diagnosis

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Berlin, Germany

Carsten Hessenius