Protein Technologies, Inc.

Carsten Grotzinger

Carsten Hessenius

Ralph-Th Roeder

Oliver Johannes Kreuzer

Volker Johannson

This invention relates to an apparatus for simultaneously carrying out multiple and highly parallel synthesis of compounds based on the solid-phase synthesis technique, in particular, peptide synthesis. Time-consuming and costly multiple rinsing processes required in solid-phase synthesis after distributing and replacing the reagents can be avoided by proposing an improved apparatus for fully automatic synthesis and subsequent separation of the synthesized compounds that involves separate synthesizer pinsfor each synthetic unit with a reagent reservoirand individual dosing capability. These synthesizer pinsare provided in a separate holderfrom where they are picked up by the gripper armof the automatic synthesizer. The openings of the reaction chambersof the synthesizer platesare closed (covered) by a permeable materialfor contamination-free placement of the synthesizer pinsand adding reagent doses to the solid or liquid phases. In addition, a sample platethat collects the samples dissolved after separation is provided underneath the valve block(see FIG.).

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Berlin, Germany

Carsten Grotzinger