Gruenenthal Gmbh

Grunenthal Gmbh

Carsten Griebel

Stefan Pruehs

Dagmar Kaulartz

Bernd Sundermann

Helmut Heinrich Buschmann

Werner Guenter Englberger

Klaus Schiene

Hagen-Heinrich Hennies

Achim Kless

Oswald K Zimmer

Derek John Saunders

Wolfgang Hell

Stefanie Frosch

Heinz Graubaum

Petra Bloms-Funke

Fritz Theil

Sven Frormann

Claudia Katharina Puetz

Ivars Graudums

Marita Mueller

Hans-Joachim Gais

Sabine Reinardy

Stefan Pruhs

Stefan Prühs

A process for the preparation of (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4&#x2032;,9&#x2032;-dihydro-3&#x2032;H-spiro[cyclohexane-1,1&#x2032;-pyrano[3,4b]indol]-4-amine and (1r,4r)-6&#x2032;-fluoro-N-methyl-4-phenyl-4&#x2032;,9&#x2032;-dihydro-3&#x2032;H-spiro[cyclohexane-1,1&#x2032;-pyrano[3,4b]-indol]-4-amine or physiologically acceptable acid addition salts thereof.

Process for the preparation of (1r,4r)-6'-fluoro-(N,N-dimethyl- and N-methyl)-4-phenyl-4&#x2032;,9&#x2032;-dihydro-3&#x2032;H-spiro[cyclohexane-1,1&#x2032;-pyrano-[3,4,b]indol]-4-amine

A method of synthesizing a substituted aminocyclohexanone compound comprising reacting a compound of formula (II) with an organolithium compound to form a compound of formula (III) 

Method for synthesizing substituted aminocyclohexanone compounds

Saturated and unsaturated heteroarylcycloalkylmethyl-amine compounds corresponding to formula I, processes for their preparation, pharmaceutical formulations comprising these compounds and the use of saturated and unsaturated heteroarylcycloalkylmethyl-amines for the preparation of pharmaceutical formulations. pharmaceutical formulations and related methods of treatment or prophylaxis of certain condition, especially depression and/or pain, are also disclosed.

Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants

The invention relates to a process for the enzymatic cleavage of racemates of aminomethyl-aryl-cyclohexanol derivatives.

Method for the enzymatic resolution of the racemates of aminomethyl-aryl-cyclohexanol derivatives

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Aachen, Germany

Carsten Griebel