Centre National De La Recherche Scientifique

Universitè De Montpellier

Institut Curie

Abivax

Universite Montpellier 2

Societe Splicos

Carsten Brock

Jamal Tazi

Didier Scherrer

Romain Najman

Florence Mahuteau

Pierre Roux

Gilles Gadea

Nathalie Cahuzac

Aude Garcel

Julien Santo

Noelie Campos

A compound of formula (I): wherein A and A' independently represent a phenylene group or a pyridylene group; Ris a hydrogen atom or a (C-C)alkyl group; Ris a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; Ris a carbonyl group or a sulfonyl group; and Ris a &#x2014;NH&#x2014;(CH)&#x2014;NRRgroup or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, Rand Rrepresenting independently a (C-C)alkyl group, or Rand Rtogether with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.

Compounds useful for treating cancer

The present invention relates to a compound of formula (I):  wherein A and A' independently represent a phenylene group or a pyridylene group; Ris a hydrogen atom or a (C-C)alkyl group; Ris a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; Ris a carbonyl group or a sulfonyl group; and Ris a &#x2014;NH&#x2014;(CH)&#x2014;NRRgroup or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, Rand Rrepresenting independently a (C-C)alkyl group, or Rand Rtogether with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.

The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and/or premature aging. The compounds of formula (Ia) being: where:

Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging

The present invention relates to a compound of formula (I): wherein A and A' independently represent a phenylene group or a pyridylene group; Ris a hydrogen atom or a (C-C)alkyl group; Ris a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; Ris a carbonyl group or a sulfonyl group; and Ris a &#x2014;NH&#x2014;(CH)&#x2014;NRRgroup or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, Rand Rrepresenting independently a (C-C)alkyl group, or Rand Rtogether with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.

A method of preventing, inhibiting, or treating cancer that includes contacting a cell with at least one compound of formula (Ia) or a pharmaceutically acceptable salt thereof: where:

Compounds for treating cancer

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Montpellier, France

Carsten Brock