Abbott Laboratories Corporation

Carroll Wayne Ours

Jaroslav Kyncl

Peter Hadley Jones

Cheuk M Lee

Yvonne Connolly Martin

Kathleen Riley Lynn

Pitambar Somani

Described are compounds of the formula ##STR1## wherein ##STR2## wherein Z is hydrogen or loweralkyl, R.sub.5 and R.sub.6 may be the same or different and are hydrogen, loweralkyl or together are alkylene of 4 or 5 carbon atoms,

Hydroxyaminomethyl derivatives of benzoyl di-substituted

This invention covers diacylated derivatives of .gamma.-glutamyl dopamine selected from the group consisting of ##STR1## where R is a C.sub.1 -C.sub.12 straight or branched chain alkyl radical, a phenyl ring or a substituted phenyl ring and R' is H or a C.sub.1 -C.sub.7 alkyl, and a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful to increase the renal blood flow by being administered to warm-blooded animals by clinically accepted routes of administration such as oral, parenteral, rectal and the like.

Diacylated derivatives of .gamma.-glutamyl dopamine

Covers the esters of .gamma.-glutamyl amide of dopamine selected from the group consisting of ##STR1## where R is a C.sub.1 -C.sub.18 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of .gamma.-glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

Esters of .gamma.-glutamyl amide of dopamine

Covers a .gamma.-glutamyl amide of dopamine selected from the group consisting of ##EQU1## and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said .gamma.-glutamyl amide to increase renal blood flow by administering said amide to warm-blooded mammals.

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Zion, IL, United States of America

Carroll Wayne Ours