Life Bioscience, Inc.

3d Glass Solutions, Inc.

Carrie F Schmidt

Jeb H Flemming

Colin T Buckley

Jeff A Bullington

Roger Cook

Mark Popovich

Luis C Chenoweth

Sierra D Jarrett

Luis Chenoweth

A method of batch massively parallel die release of a die from a substrate enabling low cost mass production of with passive, system in package (SiP) or system-in-a-package, or systems-on-chip (SoC), filters and/or other devices from a glass substrate.

High efficiency die dicing and release

The present invention provides a method of forming one or more biological-binding areas on a substrate for biological-testing. The method includes activating at least a portion of a glass-ceramic substrate comprising glass and one or more metal containing compounds. The one or more metal containing compounds have a range of diameters that are less than about 300 nanometers in diameter and are spaced an average distance of at least one-half the midpoint of the diameter range apart. The one or more metals include compounds selected from metal oxides, metal nanoparticles, metal alloys, and atomic metals. The glass-ceramic substrate is heated to a temperature near the glass transformation temperature to form one or more metal nanoparticles in one or more ceramic biological-binding areas. The glass-ceramic substrate is etched to expose one or more metal. One or more biological molecules are contacted with one or more ceramic biological-binding areas to provide one or more biological testing areas with an increased binding area as compared to un-activated areas.

Method of providing a pattern of biological-binding areas for biological testing

This invention provides an inexpensive and rapid method for fabricating a high-anisotropic-etch ratio, shaped glass structures using a novel photosensitive glass composition. Structures of the photosensitive glass may include micro-channels, micro-optics, microposts, or arrays of hollow micro-needles. Furthermore, such shaped glass structures can be used to form a negative mold for casting the shape in other materials.

Compositions and methods to fabricate a photoactive substrate suitable for shaped glass structures

Methods to fabricate a photoactive substrate suitable for shaped glass structures

The present invention includes micro-sphere composition, methods of making binding assays. The present invention also includes a micro-sphere for binding biological molecules without pretreatment. The micro-sphere includes a spherical glass substrate having one or more metal nanoparticle regions that are exposed from within the glass, wherein the micro-sphere is capable of binding biological molecules without pretreatment.

Method of providing particles having biological-binding areas for biological applications

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Las Lunas, NM, United States of America

Carrie F Schmidt