Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

E.i. Dupont De Nemours and Company

Integra Lifesciences Corporation

Shriners Hospitals for Crippled Children

The Shriner's Hospital for Crippled Children

Carolyn C Compton

Ioannis V Yannas

Dennis Paul Orgill

Mark Barlow

Charles E Butler

Scott Ritterbush

Paul J Durda

The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels from healthy underlying tissue and applying a cultured epithelial autograft sheet grown from epidermal cells taken from the animal or human at a wound free site on the animal's or human's body surface. The resulting graft has excellent take rates and has the appearance, growth, maturation and differentiation of normal skin.

Method of skin regeneration using a collagen-glycosaminoglycan matrix

A method for distinguishing between carcinomatous and/or precarcinomatous colo-rectal disease and histologically similar conditions due to diseases that are not carcinomatous or precarcinomatous comprising contacting colo-rectal tissue with an antibody that binds to blood group substance H and determining the presence of carcinomatous or precarcinomatous disease upon a finding of bound antibody, or the absence of such disease upon the finding of no bound antibody.

Method for detecting carcinomatous and precarcinomatous colo-rectal

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Chestnut Hill, MA, United States of America

Carolyn C Compton