Bristol-myers Squibb Compnay

Carolyn A Weigelt

T G Murali Dhar

Jingwu Duan

Douglas G Batt

Bin Jiang

Zhonghui Lu

David Marcoux

Myra Beaudoin Bertrand

Arun Kumar Gupta

Ananta Karmakar

John E Macor

Sing-Yuen Sit

William John Pitts

Michael G Yang

Yong-Jin Wu

Guanglin Luo

Robert J Cherney

Scott Hunter Watterson

Hai-Yun Xiao

Jie Chen

Carolyn Diane Dzierba

Zili Xiao

Qingjie Liu

Yeheng Zhu

Junqing Guo

Jianliang Shi

Amy C Hart

Brian Lee Venables

Zhizhen Barbara Zheng

Lyndon A M Cornelius

Hua Gong

Anurag S Srivastava

Jason M Guernon

Qing Shi

Murugaiah Andappan Murugaiah Subbaiah

Tg Murali Dhar

Lyndon AM Cornelius

The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications. 

Aminopyrrolotriazines as kinase inhibitors

There are described ROR&#x3b3; modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating ROR&#x3b3; activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR&#x3b3; activity, for example, autoimmune and/or inflammatory disorders.

Tricyclic sulfones as ROR gamma modulators

There are described ROR&#x3b3; modulators of the formula (I), and formula (II) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating ROR&#x3b3; activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR&#x3b3; activity, for example, autoimmune and/or inflammatory disorders.

Tricyclic sulfones as ROR&#x3b3; modulators

Described are ROR&#x3b3; modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating ROR&#x3b3; activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR&#x3b3; activity, for example, autoimmune and/or inflammatory disorders. 

Carbocyclic sulfone ROR&#x3b3; modulators

Cyclohexyl sulfone ROR&#x3b3; modulators

Growing community of inventors

Langhorne, PA, United States of America

Carolyn A Weigelt