Centre National De La Recherche Scientifique

Université De Poitiers

Université Joseph Fourier

Caroline Norez

Frédéric Becq

Jean-Luc Decout

Frederic Becq

Christel Routaboul

A treatment of cystic fibrosis by administration of a pharmaceutically acceptable amount of the glucosidase inhibitor NB-DMJ (N-butyldeoxy-mannojirimycin).

Use of glucosidase inhibitors for therapy of mucovisidosis

A method provides for the use of glycosidase inhibitors selected from compounds of general formula (1), wherein Rrepresents a CHgroup, or CHOH, Rrepresents H or an alkyl group having 1-5 carbon atoms, or Rand Rtogether form a group having formula (II), with carbon in position (a) and nitrogen of formula (I) mentioned above, for the preparation of a medicament used to treat mucovisidosis. A corresponding product is also described.

The invention concerns pharmaceutical formulas designed for the treatment of diseases related to CFTR channel dysfunction, such as cystic fibrosis, asthma or diarrhoea. These formulas contain a molecule, coming in the form of a zwitterion at physiological pH, with the general formula: where X&#x2550;N or P; and A representative example is: 

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Saint Priest, France

Caroline Norez