Glaxo Group Limited

Smithkline Beecham Corporation

Caroline Mary Cook

Stephen Swanson

Suzanne Elaine Keeling

Duncan B Judd

Paul Spencer Jones

Lee Andrew Harrison

Mika Lindvall

Colin David Eldred

Xiao Qing Lewell

Alison Judith Redgrave

Simon Teanby Hodgson

Martin Redpath Johnson

Paul Martin Gore

Christopher David Edlin

Graeme Michael Robertson

Diane Mary Coe

Julie Nicole Hamblin

Hazel Joan Dyke

David E Bays

Charlotte Jane Mitchell

Anthony William James Cooper

Chuen Chan

Brian Cox

Frank Ellis

David George Allen

Richard Peter Charles Cousins

Joanna Victoria Geden

Rachael Anne Ancliff

Siegfried B Christensen, Iv

Michael D Dowle

Naimisha Trivedi

Caroline Whitworth

Heather Hobbs

John Edward Robinson

Lionel Trottet

Amyn Pyarali Sayani

Mark Wilkinson

Andrew John Walker

Rachael Ann Ancliff

Gail Mills

Martin Alistair Hayes

The invention provides 4-{[1-(aminocarbonyl)-4-piperidinyl]amino}-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, which is the compound of formula (I): or a salt thereof.

Pyrazolo[3,4-b]pyridine compound, and its use as a PDE4 inhibitor

Morpholinyl-urea derivatives for use in the treatment of inflammatory diseases

The invention relates to a compound of formula (I) or a salt thereof: wherein: Ris Calkyl, Cfluoroalkyl or &#x2014;(CH)OH; Ris a hydrogen atom (H), methyl or Cfluoroalkyl; Ris a hydrogen atom (H) or Calkyl; Ris optionally substituted branched Calkyl, optionally substituted Ccycloalkyl, optionally substituted mono-unsaturated-Ccycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc): in which nand nindependently are 1 or 2; and Y is O, S, SO, or NR; and wherein Het is of sub-formula (i), (ii), (iii), (iv) or (v): The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.

Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors

The invention relates to a compound of formula (I) or a salt thereof: wherein: Ris Et, n-Pr, i-Pr, Cfluoroalkyl, or &#x2014;CHCHOH; wherein Ris methyl or ethyl; Ris H, methyl or ethyl; Ris H, methyl or ethyl, Ris H, methyl or ethyl, and Ris H or methyl, These compounds are PDE4 inhibitors.

[object Object]

There are provided according to the invention, novel compounds of formula (I) wherein R, R, R, R, R, R, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Compounds useful in the treatment of inflammatory diseases

The present invention relates to novel morpholin-acetamide compounds of formula (I) useful for the treatment of inflammatory diseases. Compounds of formula (I)wherein R, R, R, R, R, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Morpholin-acetamide derivatives for the treatment of inflammatory diseases

There are disclosed according to the invention, compounds of formula (I) wherein R , R and R are defined in the specification. Additionally, processes of preparing the compounds of formula (I), formulations containing same, and the administration of said compounds or formulations thereof in the treatment of inflammatory diseases are also disclosed.

2-(purin-9-yl)-tetrahydrofuran-3, 4-diol derivatives

A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.

2-(purin-9-yl)-Tetrahydrofuran-3,4-diol derivatives

Growing community of inventors

Stevenage, United Kingdom

Caroline Mary Cook