Geltex Pharmaceuticals, Inc.

Genzyme Corporation

Caroline Isabelle Bacon Kurtz

Richard Fitzpatrick

W Harry Mandeville, Iii

Chad Cori Huval

Thomas X Neenan

The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.

Anionic polymers as toxin binders and antibacterial agents

A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

Ionic polymers as toxin-binding agents

Anionic polymers as toxin binders and antibacterial agent

Anionic polymers as toxin binders

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Sudbury, MA, United States of America

Caroline Isabelle Bacon Kurtz