Genentech, Inc.

Other

The Brigham and Women's Hospital, Inc.

Indiana University

Genetech, Inc.

Caroline Alice Hebert

Kyung Jin Kim

Sherman Fong

Steven R Leong

Anan Chuntharapai

James M Lee

K Jin Kim

Claire M Doerschuk

James Coleman Lee

Mark W Moore

Michael A Gimbrone, Jr

Joffre B Baker

Martin S Obin

Rhona C Kabakoff

Methods are provided for the treatment of asthma with anti-IL-8 monoclonal antibodies.

Anti-IL-8 monoclonal antibodies for treatment of asthma

cDNAs encoding a class of receptors, including the IL-8 receptors, have been identified in human tissue. Recombinantly produced PF4ARs are used in the preparation and purification of antibodies capable of binding to the receptors, and in diagnostic assays. The antibodies are advantageously used in the prevention and treatment of inflammatory conditions.

Antibodies to PF4A receptor

Antibodies to a human PF4 superfamily receptor

Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.

Methods for treating ulcerative colitis

Anti-IL-8 monoclonal antibodies for treatment of inflammatory disorders

Methods for treating bacterial pneumonia

Anti-IL-8 antibody fragments

Antibodies to human IL-8 type A receptor

A novel polypeptide [Ala IL-8].sub.77 is provided which is a potent modulator of neutrophil functions. The polypeptide factor and related compositions find use as anti-inflammatory agents and as therapeutics for clinical indications in which damage to vascular endothelium and other tissues occurs. The amino acid and nucleotide sequence of the factor and methods for its purification, recombinant production and pharmaceutical use are provided.

[ALA IL-8].sub.77 and [SER IL-8].sub.72 as Leukocyte adhesion inhibitors

cDNAs encoding a class of receptors, including the IL-8 type B receptor, have been identified in human tissue. Recombinantly produced IL-8 type B receptor is used in the preparation and purification of antibodies capable of binding to the receptor, and in diagnostic assays. The antibodies are advantageously used in the prevention and treatment of inflammatory conditions.

Antibodies to human IL-8 type B receptor

Growing community of inventors

San Francisco, CA, United States of America

Caroline Alice Hebert