Turnstone Limited Partnership

Ottawa Hospital Research Institute

Carolina Solange Ilkow

John Cameron Bell

Jean-Simon Diallo

Fabrice Le Boeuf

Rozanne Arulanandam

Victoria Ann Maher

Briana Livia Rollande Samson

Fabrice Robert Le Boeuf

The present disclosure provides a miRNA hairpin that, when processed by a virus-infected cell, increases the therapeutic effectiveness of the virus. The present disclosure also provides a virus encoding such a miRNA hairpin. The present disclosure also provides pre-miRNAs that, when processed by a virus-infected cell, increase extracellular vesicle secretion of the encoded miRNA hairpin by the virus-infected cell.

MicroRNA-based compositions and methods used in disease treatment

Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. An oncolytic virus having a genome that includes an open reading frame that encodes FGF2 protein or a functional variant thereof is also described.

Compositions and methods for enhancing virus replication

Growing community of inventors

Ottawa, Canada

Carolina Solange Ilkow