National Institutes of Health, a Component of the US Dept. of Health & Human Services

Carole Ac Sourbier

Leonard M Neckers

John A Beutler

W Marston Linehan

Jane B Neckers

Min-Jung Lee

Bradley T Scroggins

Disclosed are methods of treating an animal for insulin resistance and associated diseases or conditions, activating the transcriptional activity of heat shock factor 1 (HSF1), or inducing the expression of heat shock protein 70 (HSP70) in an animal in need thereof, wherein the methods involve administering an effective amount of one or more compounds of formula (I) or an epimer thereof, wherein Ar, and R-Rare described herein. Examples of diseases or conditions associated with insulin resistance include diabetes, obesity, inflammation, metabolic syndrome, polycystic ovary disease, arteriosclerosis, non-alcoholic fatty liver disease, reproductive abnormality in a female, and growth abnormality. 

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Rockville, MD, United States of America

Carole Ac Sourbier