Amgen Research (munich) Gmbh

Amgen Research Gmbh

Carola Steiger

Peter Kufer

Tobias Raum

Patrick Hoffmann

Doris Rau

Roman Kischel

Matthias Klinger

Evelyne Schaller

Petra Fluhr

Susanne Hausmann

Ralf Lutterbüse

Susanne Mangold

Ralf Lutterbuese

Ralf Lutterbuse

The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.

Cross-species-specific PSMAxCD3 bispecific single chain antibody

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Munich, Germany

Carola Steiger