Agilent Technologies, Inc.

Abaxis, Inc.

Alverix, Inc.

Hewlett-packard Company

Other

Carol T Schembri

Michael P Caren

Arthur Schleifer

Peter G Webb

Tammy L Burd

Douglas A Amorese

William H McAllister

Daniel Bernardo Roitman

Anne R Kopf-Sill

Rene P Helbing

Phillip W Barth

Ian Hardcastle

John Francis Petrilla

Steven M Lefkowitz

Victor Lim

Michel G M Perbost

Adrienne Mccampbell

Charles Z Hotz

SueAnn C Dahm

Roy H Kanemoto

Leslie B Overman

Nazumi Alice Yama-Dang

Hongfeng Yin

Nicholas Michael Sampas

Steven N Buhl

Zhenghua Ji

David A King

Julie Elizabeth Fouquet

Edward P Donlon

David Ridgway Otis, Jr

Bo U Curry

Kyle J Schleifer

Mel N Kronick

Joseph P Fredrick

Bhaskar Bhayani

Chi-Sou Yu

Thuy N Tang

Matthew Marton

Vladimir E Ostoich

Richard O Hilson

Donald J Schremp

Laurence R Shea

Laurakay Bruhn

Rene B Helbing

John S Hinchcliffe

Boris Braynin

Branko Huc

Christian Skieller

Terri Bogart

Philip A Harding

Kimberly L Tam

Dianne Rees

Barnett E Saunders

Young-Ping Hwung

Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.

Deparaffinization of tissue by electric field generation and ionization

A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.

Multiple analyte detection systems and methods of detecting multiple analytes

The present disclosure related to apparatus and methods for removing waste of debris from a microtome blade, a microtome blade holder, or both. The invention also relates to automated systems and methods for cleaning a microtome.

Microtome blade and/or microtome blade holder cleaning using adhesive material

A test system includes an optical medium, a binding agent capable of capturing a target complex, and a light detector. The optical medium provides a light path, and the binding agent is positioned to hold the target complex in an evanescent field created by propagation of light along the light path. The complex interacts with the evanescent field and emits light that the detector positioned to detect. The optical medium and the detector can be included in an optical integrated circuit where detected light passes through the optical medium transverse to the direction of the light path.

Methods and materials for detection of target species

A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid.

Method for mixing a film of fluid

The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors comprise siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.

Modified siphons for improving metering precision

Methods and devices are disclosed for microarray analysis. In one embodiment a method is disclosed for processing a non-standard size slide having an array of chemical compounds attached to a surface of the slide. A sample is exposed to the surface of the non-standard size slide wherein components in the sample bind to the chemical compounds on the surface of the slide. The sample and the slide are incubated under conditions for carrying out the binding reactions, and the surface of the non-standard size slide is examined for the results of the binding reactions. Prior to the exposing step or the incubating step or the examining step, the non-standard size slide is placed into a slide holder comprising a slide-holding section a slide-holding section adapted to dispose the non-standard size slide to a processing instrument in a manner similar to that for a standard size slide. The non-standard size slide may also include an identifier such as a bar code.

Manufacture and use of non-standard size microarray slides

A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.

Method of testing multiple fluid samples with multiple biopolymer arrays

Methods, apparatus, and computer program products to form arrays of polymers each having a pattern of features on a surface of a flexible elongated web, comprising. In a method polymers or their precursor units are applied at an application station to the surface. Multiple features are covered at a reagent station with a continuous volume of reagent which chemically reacts with precursors or the web. The flexible elongated web is driven in a lengthwise direction through the application station. This sequence may be repeated as needed to form the arrays along the web. Also provided is a method preparing a surface of a flexible elongated web to receive a biopolymer array.

Chemical arrays

Flexible array substrates having a flexible support, a flexible base, a reflective layer, and a transparent layer, in that order, are taught. Methods of forming the flexible array substrates, devices incorporating flexible array substrates, and arrays having probes arranged on a surface of the flexible array substrate are also taught.

Composite flexible array substrate having flexible support

Devices having microfluidic features and arrays joined to electronics components are described. In an embodiment, the array includes a flexible array substrate. The electronics components have circuitry that may e.g. detect reactions or control conditions on the device via a feedback loop. Modular architecture provides for different combinations of microfluidic components, array components, and/or electronics components that can be used to create customized processing and analysis tools.

Device with integrated microfluidic and electronic components

Growing community of inventors

San Mateo, CA, United States of America

Carol T Schembri