Icos Corporation

Regeneron Pharmaceuticals, Inc.

Vlst Corporation

Euroscreen S.a. Icos Corporation

Euroscreen S.a.

Carol J Raport

Patrick W Gray

Vicki Louise Schweickart

Ronald Godiska

Dan Allison

David H Chantry

Michael C Deeley

Vicki L Schwickart

Vicki L Schweickart

An antikine antibody binds to two, three, four, five or more CC chemokines, such as RANTES/CCL5, MIP-1&#x3b1;/CCL3, MIP-1&#x3b2;/CCL4, or MCP-1/CCL2. Methods for affinity maturation and humanization of antikine antibodies as well as the production of hybridoma cell lines producing antikine antibodies by sequential immunization are also disclosed.

Antikine antibodies that bind to multiple CC chemokines

The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptor fragments, ligands, modulators, and antibodies are useful in the detection and treatment of disease states associated with the chemokine receptors such as atherosclerosis, rheumatoid arthritis, tumor growth suppression, asthma, viral infection, AIDS, and other inflammatory conditions.

Method of screening for modulators of HIV infection

The present invention provides purified and isolated polynucleotide sequences encoding a novel macrophage-derived C&#x2014;C chemokine designated 'Macrophage Derived Chemokine' (MDC), and polypeptide fragments and analogs thereof. Also provided are materials and methods for the recombinant or synthetic production of the chemokine, fragments, and analogs; and purified and isolated chemokine protein, and polypeptide fragments and analogs thereof. Also provided are antibodies reactive with the chemokine and methods of making and using all of the foregoing. Also provided are assays for identifying modulators of MDC chemokine activity.

Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof

Antibodies to chemokine receptor 88C

The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C-C chemokine designated Macrophage Derived Chemokine (MDC), and polypeptide analogs thereof. Also provided are materials and methods for the recombinant production of the chemokine, and purified and isolated chemokine protein, and polypeptide analogs thereof. Also provided are antibodies reactive with the chemokine and methods of making and using all of the foregoing.

Methods of identifying agents that modulate the binding between MDC and an MDC receptor

Chemokine receptor 88-C

The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptor fragments, ligands, modulators, and antibodies are useful in the detection and treatment of disease states associated with the chemokine receptors such as atherosclerosis, rheumatoid arthritis, tumor growth suppression, asthma, and other inflammatory conditions.

Polynucleotides encoding chemokine receptor 88C

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Bothell, WA, United States of America

Carol J Raport