The Dow Chemical Company

Carol C Epstein

Patrick J Oriel

Roberta C Cheng

Norman G Moll

Karen M McCoy

Robert A Houtchens

Sharonkay E Foley

Extracellular enzymes are stabilized with a carboxyalkylated or phosphonoalkylated polymer having a molecular weight of at least 500 Daltons. Exemplified is the stabilization of the enzyme glucose isomerase used in a process to convert D-glucose to D-fructose. In a preferred embodiment of the invention the feedstream containing the substrate is contacted initially with the stabilizer and then with the enzyme. In this system the stabilizer and enzyme are maintained in separate reactors. This separation, advantageously, results in a higher half-life for the enzyme.

Stabilization of glucose isomerase

The production of a heat stable glucose isomerase from a microorganism belonging to the genus Ampullariella and a method for using the isomerase to convert glucose to fructose.

Isomerization of glucose to fructose using glucose isomerase from

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Midland, MI, United States of America

Carol C Epstein