E. R. Squibb Sons, Inc.

Carol A Aklonis

Joseph O'Sullivan

Donald R Kirsch

Pushpa Singh

J Scott Wells

Adrienne A Tymiak

Helen A Ax

Cultivation of a strain of the microorganism Dactylosporangium sp. A.T.C.C. No. 53693, yields the antibiotic substance EM5586 which contains the novel useful components dactylocycline A and dactylocycline B.

Dactylocycline A and dactylocycline B

A compound having the formula ##STR1## can be prepared by enzymatically coupling a compound of the formula ##STR2## with a compound of the formula ##STR3## in the presence of Escherichia coli acylase at a pH of from about 4.0 to about 6.0.

Process for preparing (3S)-3-[[[2-(protected or unprotected

Plastatin, an inhibitor of the enzyme phospholipase A.sub.2, can be prepared by cultivating Penicillium chermesinum under submerged aerobic conditions.

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North Brunswick, NJ, United States of America

Carol A Aklonis